Esteatose Pancreática
Palavras-chave:
Pâncreas gorduroso, esteatose pancreática, doença pancreática gordurosa não alcóolicaResumo
A esteatose pancreática representa o acúmulo de gordura no pâncreas em indivíduos com consumo alcoólico considerado mínimo ou insignificante, cuja patogênese ainda não é bem compreendida e de significado clínico emergente. Uma ampla gama de termos têm sido usada para descrever esta nova entidade, não havendo ainda uma uniformização na descrição destes achados, nem uma padronização nos critérios diagnósticos, os quais devem ser buscados ao longo dos próximos anos. É sabido, no entanto, que o desenvolvimento da esteatose pancreática se correlaciona com a presença de comorbidades associadas à síndrome metabólica, especialmente a obesidade central e o diabetes, o que sugere que esta seja a expressão pancreática da disfunção metabólica sistêmica. Além desta, a lipossubstituição apresenta prevalência crescente em indivíduos de idade avançada, mas que, no entanto, parece ter um curso benigno, diferentemente da infiltração gordurosa do órgão, a qual promove o desenvolvimento de um microambiente pró-inflamatório/fibrótico. As implicações clínicas da doença pancreática gordurosa não alcoólica vêm sendo cada vez mais estudadas, e a maior incidência de pancreatite aguda, fístulas, insuficiência exócrina e desenvolvimento neoplásico parecem ocorrer em sua presença, e traremos as evidências existentes até o momento, à luz do conhecimento atual.
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